{"id":114,"date":"2019-03-22T15:43:19","date_gmt":"2019-03-22T06:43:19","guid":{"rendered":"https:\/\/www.ina-research.co.jp\/?page_id=114"},"modified":"2024-04-17T16:28:16","modified_gmt":"2024-04-17T07:28:16","slug":"thesis","status":"publish","type":"page","link":"https:\/\/ina-wp7-en.enomad.biz\/ja\/service\/thesis","title":{"rendered":"\u767a\u8868\u8ad6\u6587"},"content":{"rendered":"\n<h1 class=\"wp-block-heading font-size32 margin_b_30\">\u767a\u8868\u8ad6\u6587<\/h1>\n\n\n\n<figure class=\"wp-block-image margin_b_40\"><img loading=\"lazy\" decoding=\"async\" width=\"715\" height=\"214\" src=\"https:\/\/ina-wp7-en.enomad.biz\/wp-content\/uploads\/2019\/03\/03_04_00_00_00_mv.png\" alt=\"\" class=\"wp-image-1116\" srcset=\"https:\/\/ina-wp7-en.enomad.biz\/wp-content\/uploads\/2019\/03\/03_04_00_00_00_mv.png 715w, https:\/\/ina-wp7-en.enomad.biz\/wp-content\/uploads\/2019\/03\/03_04_00_00_00_mv-300x90.png 300w\" sizes=\"auto, (max-width: 715px) 100vw, 715px\" \/><\/figure>\n\n\n\n<p class=\"margin_b_60 wp-block-paragraph\">\u65b0\u65e5\u672c\u79d1\u5b66\u30a4\u30ca\u30ea\u30b5\u30fc\u30c1\u30bb\u30f3\u30bf\u30fc\u304c\u767a\u8868\u3057\u305f\u8ad6\u6587\u3092\u304a\u77e5\u3089\u305b\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading line-blue\">\u767a\u8868\u8ad6\u6587\uff082009-\uff09<\/h2>\n\n\n\n<figure class=\"wp-block-table table margin_b_30\"><table><tbody><tr><th><div style=\"width:4em;\"><strong>\u767a\u8868\u5e74<\/strong><\/div><\/th><th><strong>\u767a\u8868\u8ad6\u6587<\/strong>\uff08\u5171\u8457\u542b\u3080\uff09<\/th><\/tr><tr><td>2023<\/td><td>\u7530\u4e2d\u76f4\u5b50, \u963f\u90e8\u6d69\u5e78, \u8352\u6728\u7d00\u5e06, \u77f3\u4e95\u5321, \u4e0a\u91ce\u9ad8\u55e3, \u9ed2\u7530\u62d3\u4e5f, \u4f50\u6cbb\u5927\u4ecb, \u4e2d\u6751\u548c\u9756, \u5357\u4fdd\u6cf0\u5e0c, \u897f\u7530\u4ec1, \u5742\u6771\u6e05\u5b50, \u85e4\u7530\u5927\u6a39, \u677e\u6d66\u54f2\u4e5f, \u4e09\u6d66\u5de7, \u4e09\u6728\u5065\u6b21, \u671b\u6708\u79c0\u7f8e, \u5b89\u7530\u667a, \u5409\u672c\u5c06\u6210, \u6e21\u8fba\u590f\u5df3, \u4f50\u85e4\u967d\u6cbb\uff1a\u7d30\u80de\u52a0\u5de5\u88fd\u54c1\u306e\u816b\u760d\u5f62\u6210\u30ea\u30b9\u30af\u306e\u5408\u7406\u7684\u8a55\u4fa1\u3092\u76ee\u6307\u3057\u3066(1) -\u30b2\u30ce\u30e0\u4e0d\u5b89\u5b9a\u6027\u8a55\u4fa1\u306b\u95a2\u3059\u308b\u5404\u6975\u898f\u5236\u306e\u73fe\u72b6\u306b\u3064\u3044\u3066\u306e\u8abf\u67fb\u7814\u7a76-. \u518d\u751f\u533b\u7642 22(1): 30-35\uff0c2023<\/td><\/tr><tr><td>2023<\/td><td>\u7530\u4e2d\u76f4\u5b50, \u963f\u90e8\u6d69\u5e78, \u8352\u6728\u7d00\u5e06, \u77f3\u4e95\u5321, \u4e0a\u91ce\u9ad8\u55e3, \u9ed2\u7530\u62d3\u4e5f, \u4f50\u6cbb\u5927\u4ecb, \u4e2d\u6751\u548c\u9756, \u5357\u4fdd\u6cf0\u5e0c, \u897f\u7530\u4ec1, \u5742\u6771\u6e05\u5b50, \u85e4\u7530\u5927\u6a39, \u677e\u6d66\u54f2\u4e5f, \u4e09\u6d66\u5de7, \u4e09\u6728\u5065\u6b21, \u671b\u6708\u79c0\u7f8e, \u5b89\u7530\u667a, \u5409\u672c\u5c06\u6210, \u6e21\u8fba\u590f\u5df3, \u4f50\u85e4\u967d\u6cbb\uff1a\u7d30\u80de\u52a0\u5de5\u88fd\u54c1\u306e\u816b\u760d\u5f62\u6210\u30ea\u30b9\u30af\u306e\u5408\u7406\u7684\u8a55\u4fa1\u3092\u76ee\u6307\u3057\u3066(2) -\u30b2\u30ce\u30e0\u4e0d\u5b89\u5b9a\u6027\u8a55\u4fa1\u306e\u8ab2\u984c\u3068\u672a\u6765-. \u518d\u751f\u533b\u7642 22(2): 37-44\uff0c2023<\/td><\/tr><tr><td>2023<\/td><td>Thanyavi Chinsuwan, Koichi Hirabayashi, Shuji Mishima, Aiko Hasegawa, Miyuki Tanaka, Hidemi Mochizuki, Akihito Shimoi, Takashi Murakami, Shigeki Yagyu, Kimihiro Shimizu, Yozo Nakazawa: Ligand-based, piggyBac-engineered CAR-T cells targeting EGFR are safe and effective against non-small cell lung cancers. Mol Ther Oncolytics. 31:100728, 2023<\/td><\/tr><tr><td>2023<\/td><td>Thanyavi Chinsuwan, Koichi Hirabayashi, Shuji Mishima, Aiko Hasegawa, Miyuki Tanaka, Hidemi Mochizuki, Akihito Shimoi, Takashi Murakami, Shigeki Yagyu, Kimihiro Shimizu, Yozo Nakazawa: Erratum: Ligand-based, piggyBac-engineered CAR-T cells targeting EGFR are safe and effective against non-small cell lung cancers. Mol Ther Oncolytics. Mol Ther Oncolytics. 31:100735, 2023<\/td><\/tr><tr><td>2023<\/td><td>Izumi-Nakaseko H, Sakamoto K, Goto A, Kambayashi R, Matsumoto A, Takei Y, Takahara A and Sugiyama A. Characterization of pathological remodeling in the chronic atrioventricular block cynomolgus monkey heart. Frontiers in Pharmacology, Volume 14, 2023, DOI 10.3389\/fphar.2023.1055031.<\/td><\/tr><tr><td>2022<\/td><td>Hidemi Mochizuki, Susumu Suyama, So Young Youm, Pil-Su Ho, Akihito Shimoi: Characteristics of histamine H4 receptor agonist-induced allergic conjunctivitis model in Guinea pigs. Journal of Pharmacological and Toxicological Methods 119:107203, 2022<\/td><\/tr><tr><td>2022<\/td><td>Goto A, Sakamoto K, Kambayashi R, Izumi-Nakaseko H, Kawai S, Takei Y, Matsumoto A, Kanda Y, and Sugiyama A. Validation of Risk-Stratification Method for the Chronic Atrioventricular Block Cynomolgus Monkey Model and Its Mechanistic Interpretation Using 6 Drugs With Pharmacologically Distinct Profile. Toxicological sciences, 190(1), 99\u2013109, 2022.<\/td><\/tr><tr><td>2022<\/td><td>Mochizuki H, Suyama S\uff08\u5de3\u5c71\u664b\uff09, Cha JY, Ho P-S, Shimoi A. Optimization of a histamine-induced allergic conjunctivitis model in Guinea pigs. J Pharmacol Toxicol Methods.113:107133\uff0c2022<\/td><\/tr><tr><td>2021<\/td><td>Karyn Colman, Rachel N. Andrews, Hannah Atkins, Theresa Boulineau, Alys Bradley, Annamaria Braendli-Baiocco, Raffaella Capobianco, David Caudell, Mark Cline, Takuya Doi, Rainer Ernst, Eric van Esch, Jeffrey Everitt, Pierluigi Fant, Margarita M. Gruebbel, Lars Mecklenburg, Andew D. Miller, Kristen J. Nikula, Shigeru Satake, Julie Schwartz, Alok Sharma, Akihito Shimoi (\u4e0b\u4e95\u662d\u4ec1), C\u00e9cile Sobry, Ian Taylor, Vimala Vemireddi, Justin Vidal, Charles Wood, John L. Vahle. International Harmonization of Nomenclature and Diagnostic Criteria (INHAND): Non-proliferative and Proliferative Lesions of the Non-human Primate (M. fascicularis). J Toxicol Pathol 2021; 34 (3 Suppl): 1S\u2013182S<\/td><\/tr><tr><td>2021<\/td><td>Takeshi Watanabe, Satoshi Yasuda, Shinji Kusakawa, Takuya Kuroda, Mayumi Futamura, Mitsuhide Ogawa, Hidemi Mochizuki, Eri Kikkawa, Hatsue Furukawa, Masato Nagaoka, Yoji Sato: Multisite studies for validation and improvement of a highly efficient culture assay for detection of undifferentiated human pluripotent stem cells intermingled in cell therapy products. Cytotherapy 23(2):176-183, 2021<\/td><\/tr><tr><td>2021<\/td><td>Sutou S, Koeda A\uff08\u5c0f\u679d\u6681\u5b50\uff09, Kana Komatsu\uff08\u5c0f\u677e\u4f73\u5948\uff09, Shiragiku T, Seki H, Kudo T. Collaborative Study of Thresholds for Mutagens: Hormetic Responses in Cell Proliferation Tests Using Human and Murine Lymphoid Cells. Dose-response 19(2)\uff0c2021<\/td><\/tr><tr><td>2021<\/td><td>Yoda M\uff08\u4f9d\u7530\u5c06\u5b8f\uff09, Kaido T, Kamijo T, Taira C, Higuchi Y, Arai S, Okumura N. Novel variant fibrinogen \u03b3p.C352R produced hypodysfibrinogenemia leading to a bleeding episode and failure of infertility treatment. Int J Hematol. 114(3):325-333, 2021<\/td><\/tr><tr><td>2021<\/td><td>Wako Y, Hiratsuka H, Kurotaki T\uff08\u9ed2\u6edd\u54f2\u90ce\uff09, Tsuchitani M, Umemura T. Relationship between osteoid Formation and iron deposition induced by chronic cadmium exposure in ovariectomized rats. J. App. Toxicol. 41(8): 1304-1315, 2021.<\/td><\/tr><tr><td>2021<\/td><td>Enomoto M, Iwata H(\u5ca9\u7530\u8056), Iida M. Contribution of toxicologic pathologists for the safety of human health in biomedical research\u2014past, present, and future of the JSTP. J Toxicol Pathol. 2021; 34: 275\u2013282<\/td><\/tr><tr><td>2021<\/td><td>Takeshi Watanabe, Satoshi Yasuda, Shinji Kusakawa, Takuya Kuroda, Mayumi Futamura, Mitsuhide Ogawa, Hidemi Mochizuki, Eri Kikkawa, Hatsue Furukawa, Masato Nagaoka, Yoji Sato: Multisite studies for validation and improvement of a highly efficient culture assay for detection of undifferentiated human pluripotent stem cells intermingled in cell therapy products. Cytotherapy 23(2):176-183, 2021<\/td><\/tr><tr><td>2021<\/td><td>Karyn Colman, Rachel N. Andrews, Hannah Atkins, Theresa Boulineau, Alys Bradley, Annamaria Braendli-Baiocco, Raffaella Capobianco, David Caudell, Mark Cline, Takuya Doi, Rainer Ernst, Eric van Esch, Jeffrey Everitt, Pierluigi Fant, Margarita M. Gruebbel, Lars Mecklenburg, Andew D. Miller, Kristen J. Nikula, Shigeru Satake, Julie Schwartz, Alok Sharma, Akihito Shimoi (\u4e0b\u4e95\u662d\u4ec1), C\u00e9cile Sobry, Ian Taylor, Vimala Vemireddi, Justin Vidal, Charles Wood, John L. Vahle. International Harmonization of Nomenclature and Diagnostic Criteria (INHAND): Non-proliferative and Proliferative Lesions of the Non-human Primate (M. fascicularis). J Toxicol Pathol 2021; 34 (3 Suppl): 1S\u2013182S<\/td><\/tr><tr><td>2021<\/td><td>Moroki T, Matsuo S, Hatakeyama H(\u7560\u5c71\u6d0b\u6587), Hayashi S, Matsumoto I, Suzuki S, Kotera T, Kumagai K, Ozaki K. Databases for technical aspects of immunohistochemistry: 2021 update. J. 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Weight of evidence approach using a TK gene mutation assay with human TK6 cells for follow-up of positive results in Ames tests: a collaborative study by MMS\/JEMS.Genes Environ,2021;43:7<\/td><\/tr><tr><td>2021<\/td><td>Goto A, Sakamoto K(\u5742\u672c\u61b2\u543e), Kambayashi R, Nunoi Y, Izumi-Nakaseko H, Kawai S,Takei Y, Matsumoto A, Kanda Y, Sugiyama A\uff0eTorsadogenic Action of Cisapride, dl-Sotalol, Bepridil, and Verapamil Analyzed by the Chronic Atrioventricular Block Cynomolgus Monkeys: Comparison With That Reported in the CiPA In Silico Mechanistic Model\uff0eToxicological Sciences, 2021;181:125\u2013133\uff0e<br><\/td><\/tr><tr><td>2020<\/td><td>Hirokazu Morokawa, Shigeki Yagyu, Aiko Hasegawa, Miyuki Tanaka, Shoji Saito, Hidemi Mochizuki, Kengo Sakamoto, Akihito Shimoi, Yozo Nakazawa: Autologous non\u2010human primate model for safety assessment of piggyBac transposon-mediated chimeric antigen receptor T cells on granulocyte\u2013macrophage colony\u2010stimulating factor receptor. Clinical &amp; Translational Immunology 9(11), e1207, 2020<\/td><\/tr><tr><td>2020<\/td><td>Tomonari Y, Sato J, Yamada N, Kurotaki T\uff08\u9ed2\u6edd\u54f2\u90ce\uff09, Doi T, Kanno T, Tsuchitani M. Immunohistochemical characteristics of thymomas and hyperplastic lesions in wistar hannover rats. Toxicol Pathol. 48(5):649-655, 2020.<\/td><\/tr><tr><td>2020<\/td><td>Watanabe A, Miyajima K, Kemuriyama N, Uchiyama H, Anzai T, Iwata H(\u5ca9\u7530<br>\u8056), Anzai R, Nakae D. Impact of altered dietary calcium-phosphorus ratio caused by high phosphorus diets in a rat chronic kidney disease (CKD) model created by partial ligation of the renal arteries.J.Toxicol Pathol.2020;33:77-86<br><\/td><\/tr><tr><td>2020<\/td><td>Goto A, Sakamoto K(\u5742\u672c\u61b2\u543e), Hagiwara-Nagasawa M, Kambayashi R, Chiba K, Nunoi Y, Izumi-Nakaseko H, Takei Y, Matsumoto A, Sugiyama A\uff0eIn vivo analysis of the effects of intravenously as well as orally administered moxifloxacin on the pharmacokinetic and electrocardiographic variables along with its torsadogenic action in the chronic atrioventricular block cynomolgus monkeys\uff0eJournal of Pharmacological Sciences\uff0e2020;143:272-280\uff0e<br><\/td><\/tr><tr><td>2020<\/td><td>Goto A, Sakamoto K(\u5742\u672c\u61b2\u543e), Hagiwara-Nagasawa M, Kambayashi R, Chiba K, Nunoi Y, Izumi-Nakaseko H, Matsumoto A, Sugiyama A\uff0eUtilization of the chronic atrioventricular block cynomolgus monkey as an in vivo model to evaluate drug interaction-associated torsade de pointes\uff0eJournal of Pharmacological Sciences\uff0e2020;142:172-175\uff0e<br><\/td><\/tr><tr><td>2020<\/td><td>Koeda A(\u5c0f\u679d\u6681\u5b50), Iwao T, Nakanishi A, Mizuno S, Yamashita M, et al. Comparison of the inducibility of CYP mRNA exposed to typical inducers in fresh and cryopreserved cynomolgus monkey hepatocytes. Drug Metabolism and Pharmacokinetics. 2020 (in press)<br><\/td><\/tr><tr><td>2020<\/td><td>Kitoh H, Matsushita M, Mishima K, Nagata T, Kamiya Y, Urda K, Kuwatsuka Y, Morikawa H\uff08\u68ee\u5ddd\u88d5\u53f8\uff09, Nakai Y, Ishiguro N\uff0ePharmacokinetics\u3000and\u3000safety\u3000after\u3000once\u3000and\u3000twice\u3000a\u3000day\u3000doses\u3000of\u3000meclizine\u3000hydrochloride\u3000administered to chilrden with achondroplasia\uff0ePLOS ONE\uff0e15(4)\uff0c2020\uff0e<\/td><\/tr><tr><td>2020<\/td><td>Hirasawa Y\uff08\u5e73\u6fa4\u7531\u8cb4\uff09\uff0cFujiwara A\uff08\u85e4\u539f\u6df3\uff09\uff0cTabata K\uff08\u7530\u7551\u4e00\u4e5f\uff09\uff0cKenji Yoshida\uff0cTsutomu Negama\uff0cAnzai T\uff08\u5b89\u9f4b\u4eab\u5f81\uff09\uff0cSato S\uff08\u4f50\u85e4\u4f38\u4e00\uff09\uff0eEvaluation of cytokine storms in a disseminated intravascular coagulation monkey model\uff0eFundam.Toxicol.Sci.\uff0cVol.7\uff0cNo.2\uff0cpp.105-114\uff0e\uff082020\uff09<\/td><\/tr><tr><td>2020<\/td><td>Park C-W, Han C-T, Sakaguchi Y\uff08\u5742\u53e3\u9756\u6c5f\uff09, Lee J, Youn H-Y. 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Genes Environment. 2018; 40: 20.<\/td><\/tr><tr><td>2018<\/td><td>Mochizuki H(\u671b\u6708\u79c0\u7f8e), Murota N(\u5ba4\u7530\u5c1a\u54c9), Sato S(\u4f50\u85e4\u4f38\u4e00), et al. Approaches of validation of a 2-week combined repeated oral dose toxicity study with plasma micro sampling toxicokinetics (PMS-TK) in common marmosets.   The Journal of Toxicological Sciences.\u30002018; 43(11), 685-695<\/td><\/tr><tr><td>2018<\/td><td>Atsushi Fujiwara\uff08\u85e4\u539f\u6df3\uff09, Miki Shimosawa\uff08\u4e0b\u6fa4\u7f8e\u7d00\uff09, Masahiko Iino\uff08\u98ef\u91ce\u96c5\u5f66\uff09, Mikio Sasaki\uff08\u4f50\u3005\u6728\u5e79\u592b\uff09, Shin-ichi Sato\uff08\u4f50\u85e4\u4f38\u4e00\uff09, Akihito Shimoi\uff08\u4e0b\u4e95\u662d\u4ec1\uff09\uff0eGeneralization tests using different dosing routes from those of drug discrimination training in rats. 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Journal of Pharmacological Sciences\uff0e2018; 136(4), 249-256<\/td><\/tr><tr><td>2018<\/td><td>Matsuo T, Uchida T, Takei S(\u6b66\u4e95\u4fe1\u8cb4\u5b50), Ido D(\u4e95\u6238\u5927\u4ecb), Tanaka M(\u7530\u4e2d\u5b88), Oguchi M(\u5c0f\u53e3\u6b63\u592b), et al. Visual evoked potential in rabbits&#8217; eyes with subretinal implantation by vitrectomy of Okayama University-type retinal prosthesis (OURePTM). Journal of Veterinary Medical Science. 2018; 80(2), 247-259<\/td><\/tr><tr><td>2017<\/td><td>Matsuo T, Uchida T, Takei S(\u6b66\u4e95\u4fe1\u8cb4\u5b50), Ido D(\u4e95\u6238\u5927\u4ecb), Tanaka M(\u7530\u4e2d\u5b88), Oguchi M(\u5c0f\u53e3\u6b63\u592b), et al\uff0eSubretinal implantation of Okayama University-type retinal prosthesis (OURePTM) in canine eyes by vitrectomy. Journal of Veterinary Medical Science. 2017; 79(12), 1939-1946<\/td><\/tr><tr><td>2017<\/td><td>Nakata H\uff0cTsubotani Y\uff0cNii T\uff0cHagi A\uff0cInoue Y and Imamura T(\u4eca\u6751\u5321\u5fd7)\uff0eEffects of olanexidine gluconate on preoperative skin preparation: an experimental study in cynomolgus monkeys. Journal of Medical Microbiology. 2017.<\/td><\/tr><tr><td>2017<\/td><td>Kitaguchi T\uff0cOtabe K(\u5c0f\u7530\u90e8\u8015\u4e8c)\uff0cOguchi M(\u5c0f\u53e3\u6b63\u592b)\uff0cet al\uff0eCSAHi study: Detection of drug-induced ion cannnel\/receptor responses, QT prolongation, and arrhythmia using multi-electrode arrays in combination with human induced pluripotent stem cell-derived cardiomyocytes. Journal of Pharmacological and Toxicological Methods. 2017.<\/td><\/tr><tr><td>2017<\/td><td>Ando H, Tashibu H(\u7530\u6f81\u5f18\u884c), Sekino Y, et al. A new paradigm for drug-induced torsadogenic risk assessment using human iPS cell-derived cardiomyocytes. Journal of Pharmacological and Toxicological Methods. 2017; 84, 111-127.<\/td><\/tr><tr><td>2016<\/td><td>Yamamoto W,&nbsp;Tashibu&nbsp;H(\u7530\u6f81\u5f18\u884c),&nbsp;Sekino&nbsp;Y, et al. Electrophysiological Characteristics of Human iPSC-Derived Cardiomyocytes for the Assessment of Drug-Induced&nbsp;Proarrhythmic&nbsp;Potential. journal. pone. 2016; 11(12).<\/td><\/tr><tr><td>2016<\/td><td>Shiba&nbsp;Y\uff0cSakamoto K(\u5742\u672c\u61b2\u543e)\uff0cIdo&nbsp;D(\u4e95\u6238\u5927\u4ecb)\uff0cet al\uff0eAllogeneic Transplantation of&nbsp;iPS&nbsp;Cell-Derived Cardiomyocytes Regenerates Primate Hearts\uff0eNature\uff0e2016\uff1bVolume 538\uff0cOctober 20\uff0e<\/td><\/tr><tr><td>2016<\/td><td>Fujiwara A(\u85e4\u539f\u6df3), Iino M(\u98ef\u91ce\u96c5\u5f66), Sasaki M(\u4f50\u3005\u6728\u5e79\u592b). Relationship between the Dose to Produce Reinforcing Effect and that of Gross Behavioral Effects in Rhesus Monkeys. J Drug Abuse. 2016; 2:2.<\/td><\/tr><tr><td>2016<\/td><td>\u6b66\u4e95\u4fe1\u8cb4\u5b50\uff0eAAALAC International\uff08\u65e7\u56fd\u969b\u5b9f\u9a13\u52d5\u7269\u30b1\u30a2\u8a55\u4fa1\u8a8d\u8a3c\u5354\u4f1a\uff09\u306b\u3088\u308b\u8a8d\u8a3c\uff0e\u5b9f\u9a13\u52d5\u7269\u3068\u74b0\u5883\uff0e2016\uff1b 24(2)\uff1a 101-104\uff0e<\/td><\/tr><tr><td>2016<\/td><td>Kitaguchi T\uff0cOtabe K(\u5c0f\u7530\u90e8\u8015\u4e8c)\uff0cOguchi M(\u5c0f\u53e3\u6b63\u592b)\uff0cet al\uff0eCSAHi study: Evaluation of multi-electrode array in combination with human iPS cell-derived cardiomyocytes to predict drug-induced QT prolongation and arrhythimia &#8211; Effects of 7 reference compounds at 10 facilities. Journal of Pharmacological and Toxicological Methods. 2016; 78: 93-102.<\/td><\/tr><tr><td>2016<\/td><td>Fujiwara A(\u85e4\u539f\u6df3), Shimosawa M(\u4e0b\u6fa4\u7f8e\u7d00), Iino M(\u98ef\u91ce\u96c5\u5f66), Sasaki M(\u4f50\u3005\u6728\u5e79\u592b), Sato S(\u4f50\u85e4\u4f38\u4e00). Physical Dependence and Plasma Concentrations of Morphine in Rats. J Drug Abuse. 2016, 2:3.<\/td><\/tr><tr><td>2015<\/td><td>Shiina T, Yamada Y(\u5c71\u7530\u5e78\u7a42)\uff0c Ido D(\u4e95\u6238\u5927\u4ecb), Yamanaka H(\u5c71\u4e2d\u4e45), et al. Discovery of novel MHC-class I alleles and haplotypes in Filipino cynomolgus macaques (Macaca fascicularis) by pyrosequencing and Sanger sequencing: Mafa-class I polymorphism. Immunogenetics. 2015; 67(10), 563-78<\/td><\/tr><tr><td>2015<\/td><td>Onodera H, Sasaki S, Otake S, Tomohiro M, Shibuya K, Nomura M(\u91ce\u6751\u8b77). General considerations in ocular toxicity risk assessment from the toxicologists&#8217; viewpoints. The Journal of Toxicological Sciences.2015; 40(3):295-307.<\/td><\/tr><tr><td>2015<\/td><td>ELMORE S, CORA M, GRUEBBEL M, HAYES S, HOANE J, KOIZUMI H(\u5c0f\u6cc9\u6cbb\u5b50), PETERS R, ROSOL T, SINGH B, SZABO K. Proceedings of the 2014 National Toxicology Program Satellite Symposium.&nbsp;Toxicologic&nbsp;Pathology. &nbsp;2015; 43: 10-40.<\/td><\/tr><tr><td>2015<\/td><td>Hamada S, Imamura T(\u4eca\u6751\u5321\u5fd7)\uff0cet al. CSGMT(\u5171\u540c\u7814\u7a76). Evaluation of the repeated-dose liver and gastrointestinal tract micronucleus assays with 22 chemicals using young adult rats: Summary of the collaborative Study Group for CSGMT\/JEMS\uff65MMS. Mutation Research. 2015;780-781:2-17.<\/td><\/tr><tr><td>2015<\/td><td>Imamura T(\u4eca\u6751\u5321\u5fd7), Koeda A(\u5c0f\u679d\u6681\u5b50), Morimoto K(\u68ee\u672c\u6e05), Hatakeyama H(\u7560\u5c71\u6d0b\u6587), Suzuki H(\u9234\u6728\u6d0b), Wakao Y, Kawasako K, Otabe K(\u5c0f\u7530\u90e8\u8015\u4e8c), Sato S(\u4f50\u85e4\u4f38\u4e00). Evaluation of a repeated-dose liver micronucleus assay with 2,6-dinitrotoluene using young adult rats. Mutation Research. 2015;780-781:46-50.<\/td><\/tr><tr><td>2015<\/td><td>Inoue S(\u4e95\u4e0a\u7d17\u5b63),&nbsp;Yonemaru&nbsp;K,&nbsp;Yanai&nbsp;T, Sakai H. Mixed germ cell-sex cord-stromal tumor with a concurrent interstitial cell tumor in a ferret. J. Vet. Med. Sci. 2015; 77(2): 225-228.<\/td><\/tr><tr><td>2014<\/td><td>Tazawa S, Katayama S, Hirabayashi M, Yamaguchi D, Nakamura S. Improvement of Surface Functionalities, Including Allergenicity Attenuation, of Whole Buckwheat Protein Fraction by Maillard-Type Glycation with Dextran. Prev. Nutr. Food Sci. 2014; 19(4): 327-332.<\/td><\/tr><tr><td>2013<\/td><td>Nakano M, Suzuki H, Imamura T, Lau A, Lynch B. Genotoxicity of pyrroloquinoline quinone (PQQ) disodium salt (BioPQQTM). Regulatory Toxicology and Pharmacology. 2013; 67: 189-197.<\/td><\/tr><tr><td>2013<\/td><td>Ema M, Imamura T, Suzuki H, Kobayashi N, Naya M, Nakanishi J. Genotoxicity evaluation for single-walled carbon nanotubes in a battery of in vitro and in vivo assays. J. Appl. Toxicol. 2013; 33: 933-939.<\/td><\/tr><tr><td>2012<\/td><td>\u65b0\u85ac\u958b\u767a\u306b\u304a\u3051\u308b\u5fc3\u6bd2\u6027\u8a55\u4fa1\uff1b\u524d\u81e8\u5e8a\u8a66\u9a13\u3067\u306e\u7d4c\u9a13\uff0e\u7b2c14\u56de\u81e8\u5e8a\u85ac\u7406\u8a66\u9a13\u7814\u7a76\u4f1a.\u30bb\u30c3\u30b7\u30e7\u30f3II \u65b0\u85ac\u958b\u767a\u306b\u304a\u3051\u308b\u5fc3\u6bd2\u6027\u8a55\u4fa1.2012\u5e746\u67089\u65e5\u958b\u50ac\uff0e\u81e8\u5e8a\u533b\u85ac\uff0e2012\uff1b28(10);895-902.<\/td><\/tr><tr><td>2012<\/td><td>Ema M, Imamura T, Suzuki H, Kobayashi N, Naya M, Nakanishi J. Evaluation of genotoxicity of multi-walled carbon nanotubes in a battery of in vitro and in vivo assays. Regulatory Toxicology and Pharmacology. 2012; 63: 188-195.<\/td><\/tr><tr><td>2011<\/td><td>Ema M, Matsuda A, Kobayashi N, Naya M, Nakanishi J. Evaluation of dermal and eye irritation and skin sensitization due to carbon nanotubes. Regulatory Toxicology and Pharmacology. 2011;61:276-281.<\/td><\/tr><tr><td>2011<\/td><td>Umigai N, Murakami K, M.V.Ulit, L.S.Antonio, Shirotori M, Morikawa H,\u3000Nakano T. The Pharmacokinetic profile of crocetin in healthy adult human volunteers after a single oral administration. Phytomedicine. 2011;18:575-578.<\/td><\/tr><tr><td>2011<\/td><td>Suzuki H\uff0cImamura T, Koeda A, Morimoto K, Wakasa Y, Takei Y, Amemiya R, Hatakeyama H, Satoh H, Sato S. Genotoxicity studies of 2,6-dinitrotoluene (2,6-DNT). The Journal of Toxicological Sciences. 2011;36(4):499-505.<\/td><\/tr><tr><td>2010<\/td><td>\u30e2\u30ad\u30b7\u30d5\u30ed\u30ad\u30b5\u30b7\u30f3\u306e\u5065\u5eb7\u6210\u4eba\u30d5\u30a3\u30ea\u30d4\u30f3\u4eba\u88ab\u9a13\u8005\u306b\u304a\u3051\u308bQT\/QTc\u8a55\u4fa1\u8a66\u9a13. \u81e8\u5e8a\u533b\u85ac. 2010\uff1b26(12): 841-851.<\/td><\/tr><tr><td>2010<\/td><td>\u5fc3\u96fb\u56f3\u7570\u5e38\u8a55\u4fa1\u306b\u95a2\u3059\u308bICH-S7B(\u975e\u81e8\u5e8a\u8a66\u9a13) \u53ca\u3073E14(\u81e8\u5e8a\u8a66\u9a13)-\u539a\u751f\u52b4\u50cd\u7701\u901a\u77e5\u306e\u610f\u7fa9-. \u81e8\u5e8a\u8a55\u4fa1.2010\uff1b38(1): 51-56.<\/td><\/tr><tr><td>2010<\/td><td>Thorough QT\/QTc\u8a66\u9a13 (QT\/QTc\u8a55\u4fa1\u8a66\u9a13): ICH E14\u306b\u57fa\u3065\u304f\u8a66\u9a13\u306e\u5b9f\u969b\u3068\u65e5\u672c\u88fd\u85ac\u4f01\u696d\u3078\u306e\u63d0\u6848. \u81e8\u5e8a\u8a55\u4fa1.2010\uff1b38(1): 41-49.<\/td><\/tr><tr><td>2009<\/td><td>Tanaka N, Sasaki K, Hayashi K, Sakai A, Asada S, Muramatsu D, Kuroda S, Mizuhashi F, Nagai M, Suzuki H\uff0cImamura T, Asakura M, Satoh H, Sakamoto A, Nakao R, Hirose H, Ishii N, Umeda M. An Interlaboratory Collaborative Study on a Cell Transformation Assay Using Bhas 42 Cells. AATEX. 2009; 14(1): 831-848.<\/td><\/tr><tr><td>2009<\/td><td>Thorough QT\/QTc\u8a66\u9a13\uff08\u7dbf\u5bc6\u306aQT\/QTc\u8a66\u9a13\uff09-ICH\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3E14\u306b\u57fa\u3065\u304f\u8a66\u9a13\u306e\u5b9f\u969b-. \u533b\u85ac\u30b8\u30e3\u30fc\u30ca\u30eb. 2009\uff1b45(4):115-119.<\/td><\/tr><\/tbody><\/table><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>\u767a\u8868\u8ad6\u6587 \u65b0\u65e5\u672c\u79d1\u5b66\u30a4\u30ca\u30ea\u30b5\u30fc\u30c1\u30bb\u30f3\u30bf\u30fc\u304c\u767a\u8868\u3057\u305f\u8ad6\u6587\u3092\u304a\u77e5\u3089\u305b\u3057\u307e\u3059\u3002 \u767a\u8868\u8ad6\u6587\uff082009-\uff09 \u767a\u8868\u5e74 \u767a\u8868\u8ad6\u6587\uff08\u5171\u8457\u542b\u3080\uff09 2023 \u7530\u4e2d\u76f4\u5b50, \u963f\u90e8\u6d69\u5e78,<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":59,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-114","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/ina-wp7-en.enomad.biz\/ja\/wp-json\/wp\/v2\/pages\/114","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ina-wp7-en.enomad.biz\/ja\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/ina-wp7-en.enomad.biz\/ja\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/ina-wp7-en.enomad.biz\/ja\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/ina-wp7-en.enomad.biz\/ja\/wp-json\/wp\/v2\/comments?post=114"}],"version-history":[{"count":24,"href":"https:\/\/ina-wp7-en.enomad.biz\/ja\/wp-json\/wp\/v2\/pages\/114\/revisions"}],"predecessor-version":[{"id":9146,"href":"https:\/\/ina-wp7-en.enomad.biz\/ja\/wp-json\/wp\/v2\/pages\/114\/revisions\/9146"}],"up":[{"embeddable":true,"href":"https:\/\/ina-wp7-en.enomad.biz\/ja\/wp-json\/wp\/v2\/pages\/59"}],"wp:attachment":[{"href":"https:\/\/ina-wp7-en.enomad.biz\/ja\/wp-json\/wp\/v2\/media?parent=114"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}